Rejuran vs Re2O — Cheongdam & Apgujeong, Seoul

Calming repair or skin-quality rebuild?

International patients often arrive having heard of Rejuran, which has been widely used in Korea for years, and are curious about newer boosters such as Re2O. Both are injected into the skin and neither is a filler; the difference lies in emphasis.

Rejuran's polynucleotides are associated with supporting the skin's repair environment and hydration. It is typically chosen when skin is thin, dehydrated, easily irritated or recovering — when the priority is resilience and a calmer, healthier surface.

Re2O is a newer-generation booster that Doje groups with GOURI as an option for improving skin quality more broadly: density, fine texture, pores and hydration. Because product specifics are best explained against your own skin, Dr. Byun Jeik walks through how Re2O works, what it contains and what to expect during the consultation rather than relying on generic claims.

How Doje Clinic uses each

Doje organises skin care by concern rather than by product. In hydration and soothing care, Rejuran is added selectively. In pore and texture care and in hydration care, GOURI or Re2O may be used. In the Mid-Face and Marionette programmes, GOURI/Re2O is an option to improve the skin over a thread lift. Around the eyes, the Eye Program lists Eye Rejuran and Re2O Fine as separate options, so the choice can be tailored to whether the under-eye skin needs calming repair or more substance.

Side-by-side comparison

When Doje combines them

Combining two boosters is not automatic. It is considered when skin shows both fragility and lost quality — for instance, thin, reactive under-eye skin that also looks crepey and dull. In such cases Dr. Byun may use Rejuran to support resilience and Re2O to improve skin quality, spacing sessions so the skin is not overloaded. More often, one is chosen as the better fit and the other is kept in reserve for maintenance.

Which should you choose?

• Rejuran — if your skin is reactive, thin, dehydrated or recovering from other treatments.
• Re2O — if your skin is reasonably calm but looks dull, less dense or uneven in texture.
• Under the eyes — Eye Rejuran for fragile skin; Re2O Fine where more substance is the aim.
• Comparing with GOURI — see GOURI vs Re2O.

Recovery and aftercare

Keep skincare gentle, use sun protection, avoid makeup on injection points for the advised period, and skip saunas briefly. See skin booster aftercare.

Cost

Fees are quoted after a 1:1 consultation because product, area and sessions vary. Ask for a written quote; Korean non-covered (비급여) aesthetic fees are set per plan.

Frequently asked questions

What is the difference between Rejuran and Re2O?

Rejuran is a polynucleotide booster focused on repair and hydration; Re2O is a newer booster Doje uses for broader skin quality such as density and texture.

Which is better under the eyes?

It depends on the skin: Eye Rejuran suits fragile skin, while Re2O Fine may suit skin that needs more substance. Dr. Byun advises after assessment.

Is Re2O a filler?

No. It is a skin booster designed to improve skin quality rather than add shape or volume.

Can Rejuran and Re2O be combined?

Sometimes, when skin is both fragile and lacking quality. Doje spaces sessions rather than stacking them by default.

How many sessions will I need?

It varies by skin condition; some people need one session and others a short series.

Related at Doje Clinic

• Rejuran
• Re2O skin booster
• Eye Rejuran
• Dull skin
• Under-eye filler vs Eye Rejuran
• Rejuran vs GOURI

Medical information on this page is general education, not a diagnosis. Suitability, risks and the final plan are confirmed in a 1:1 consultation with Dr. Byun Jeik. Last updated 17 October 2026.