Rejuran vs Exosome — Cheongdam & Apgujeong, Seoul

Two regenerative approaches

Rejuran and exosome treatments are both described as regenerative, but they deliver different things in different ways. Rejuran is an injectable polynucleotide (PN) product. Polynucleotides are thought to support the skin's repair environment and hydration, which is why Rejuran is widely used for thin, tired or sensitised skin and for fine crepiness — including a dedicated eye version.

Exosomes are tiny vesicles that cells release to communicate with one another, carrying proteins and other signalling molecules. In aesthetic practice, exosome solutions are typically applied through microneedling channels so they reach the skin where it is actively healing. The aim is to support recovery after the microneedling and to enhance its effect on texture, pores and tone. Scientific understanding of exosomes in aesthetics is still developing, so they are best seen as a supportive component of a plan rather than a stand-alone answer.

How Doje Clinic uses each

Within Doje's skin care, Rejuran is listed under hydration and soothing, and it is added selectively rather than routinely. Eye Rejuran is an option in the Eye Program. Exosome is central to pore and texture care, where exosome + Potenza pumping and autologous exosome + Potenza are used to refine pores and uneven texture. Doje autologous exosome is also part of the One-Day Program, combined with a signature thread lift and oxygen therapy.

Side-by-side comparison

When Doje combines them

They can be combined when skin has two needs: structural repair and surface refinement. For example, someone with enlarged pores and also thin, easily irritated skin might have exosome + Potenza for texture while Rejuran supports the skin's resilience. Doje usually sequences these so the skin is never overloaded — a principle the clinic applies to devices and boosters alike. Where sensitivity or redness is the main issue, soothing and hydration care, such as skin recovery care or oxygen therapy, may come first.

Which should you choose?

• Rejuran — if your skin is thin, dehydrated, reactive or finely crepey, or you want to strengthen the eye area.
• Exosome — if pores, rough texture or post-acne unevenness are the priority and you are open to microneedling.
• Both — if you have texture concerns on top of fragile, thin skin.
• Autologous vs standard exosome — see autologous exosome vs exosome.

Recovery and aftercare

Avoid makeup on treated areas for the advised period, use gentle skincare and sun protection, and avoid saunas briefly. See skin booster aftercare.

Cost

Fees are quoted after a 1:1 consultation because product, area and session count vary. Ask for a written quote; Korean non-covered (비급여) aesthetic fees are set per plan.

Frequently asked questions

What is the difference between Rejuran and exosome?

Rejuran is an injectable polynucleotide booster for repair and hydration; exosome treatment delivers signalling vesicles, usually with microneedling, for texture and recovery.

Which is better for pores?

Exosome combined with Potenza microneedling is usually more relevant for pores and texture at Doje.

Which is better for sensitive or thin skin?

Rejuran is often chosen for thin or sensitised skin, added selectively after assessment.

What is autologous exosome?

It is an exosome preparation made from the patient's own sample. Doje explains the process and suitability in consultation.

Can I combine them?

Yes, when skin needs both repair and texture refinement. Doje sequences them to avoid overloading the skin.

Related at Doje Clinic

• Rejuran
• Exosome therapy
• Autologous exosome
• Potenza
• Enlarged pores
• Sensitive skin
• Rejuran vs GOURI

Medical information on this page is general education, not a diagnosis. Suitability, risks and the final plan are confirmed in a 1:1 consultation with Dr. Byun Jeik. Last updated 17 October 2026.